Routine preoperative (111)In-octreotide scintigraphy in patients with medullary thyroid cancer.
Identifieur interne : 000426 ( Main/Exploration ); précédent : 000425; suivant : 000427Routine preoperative (111)In-octreotide scintigraphy in patients with medullary thyroid cancer.
Auteurs : RBID : pubmed:23686276English descriptors
- KwdEn :
- Adult, Aged, Cohort Studies, Diagnostic Tests, Routine, Female, Humans, Lymph Nodes (pathology), Lymph Nodes (radionuclide imaging), Male, Middle Aged, Neoplasm Invasiveness (pathology), Neoplasm Staging, Octreotide (analogs & derivatives), Octreotide (diagnostic use), Preoperative Care (methods), Radiopharmaceuticals (diagnostic use), Retrospective Studies, Risk Assessment, Sensitivity and Specificity, Survival Analysis, Thyroid Neoplasms (mortality), Thyroid Neoplasms (pathology), Thyroid Neoplasms (radionuclide imaging), Thyroid Neoplasms (surgery), Thyroidectomy (methods), Treatment Outcome, Tumor Burden, Young Adult.
- MESH :
- chemical , analogs & derivatives : Octreotide.
- chemical , diagnostic use : Octreotide, Radiopharmaceuticals.
- methods : Preoperative Care, Thyroidectomy.
- mortality : Thyroid Neoplasms.
- pathology : Lymph Nodes, Neoplasm Invasiveness, Thyroid Neoplasms.
- radionuclide imaging : Lymph Nodes, Thyroid Neoplasms.
- surgery : Thyroid Neoplasms.
- Adult, Aged, Cohort Studies, Diagnostic Tests, Routine, Female, Humans, Male, Middle Aged, Neoplasm Staging, Retrospective Studies, Risk Assessment, Sensitivity and Specificity, Survival Analysis, Treatment Outcome, Tumor Burden, Young Adult.
Abstract
Surgery is the only potential cure for patients with medullary thyroid carcinoma (MTC). Preoperative ultrasound, computed tomography and magnetic resonance imaging are not sensitive enough for detection of microscopic disease. The aim of this study was to investigate if routine preoperative (111)In-labelled (DTPA-D-Phe(1))-octreotide scintigraphy (SRS) could be used as a staging procedure in planning primary surgery in patients with MTC.
DOI: 10.1007/s00423-013-1086-1
PubMed: 23686276
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Routine preoperative (111)In-octreotide scintigraphy in patients with medullary thyroid cancer.</title><author><name sortKey="Dahlberg, Jakob" uniqKey="Dahlberg J">Jakob Dahlberg</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden. jakob.dahlberg@vgregion.se</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Surgery, Sahlgrenska University Hospital, 413 45 Gothenburg</wicri:regionArea></affiliation></author><author><name sortKey="B Mming, Per" uniqKey="B Mming P">Per Bümming</name></author><author><name sortKey="Gjertsson, Peter" uniqKey="Gjertsson P">Peter Gjertsson</name></author><author><name sortKey="Jansson, Svante" uniqKey="Jansson S">Svante Jansson</name></author></titleStmt><publicationStmt><date when="2013">2013</date><idno type="doi">10.1007/s00423-013-1086-1</idno><idno type="RBID">pubmed:23686276</idno><idno type="pmid">23686276</idno><idno type="wicri:Area/Main/Corpus">000609</idno><idno type="wicri:Area/Main/Curation">000609</idno><idno type="wicri:Area/Main/Exploration">000426</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Cohort Studies</term><term>Diagnostic Tests, Routine</term><term>Female</term><term>Humans</term><term>Lymph Nodes (pathology)</term><term>Lymph Nodes (radionuclide imaging)</term><term>Male</term><term>Middle Aged</term><term>Neoplasm Invasiveness (pathology)</term><term>Neoplasm Staging</term><term>Octreotide (analogs & derivatives)</term><term>Octreotide (diagnostic use)</term><term>Preoperative Care (methods)</term><term>Radiopharmaceuticals (diagnostic use)</term><term>Retrospective Studies</term><term>Risk Assessment</term><term>Sensitivity and Specificity</term><term>Survival Analysis</term><term>Thyroid Neoplasms (mortality)</term><term>Thyroid Neoplasms (pathology)</term><term>Thyroid Neoplasms (radionuclide imaging)</term><term>Thyroid Neoplasms (surgery)</term><term>Thyroidectomy (methods)</term><term>Treatment Outcome</term><term>Tumor Burden</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Octreotide</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Octreotide</term><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Preoperative Care</term><term>Thyroidectomy</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Thyroid Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymph Nodes</term><term>Neoplasm Invasiveness</term><term>Thyroid Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Lymph Nodes</term><term>Thyroid Neoplasms</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Thyroid Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Cohort Studies</term><term>Diagnostic Tests, Routine</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neoplasm Staging</term><term>Retrospective Studies</term><term>Risk Assessment</term><term>Sensitivity and Specificity</term><term>Survival Analysis</term><term>Treatment Outcome</term><term>Tumor Burden</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Surgery is the only potential cure for patients with medullary thyroid carcinoma (MTC). Preoperative ultrasound, computed tomography and magnetic resonance imaging are not sensitive enough for detection of microscopic disease. The aim of this study was to investigate if routine preoperative (111)In-labelled (DTPA-D-Phe(1))-octreotide scintigraphy (SRS) could be used as a staging procedure in planning primary surgery in patients with MTC.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">23686276</PMID><DateCreated><Year>2013</Year><Month>07</Month><Day>26</Day></DateCreated><DateCompleted><Year>2014</Year><Month>03</Month><Day>19</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1435-2451</ISSN><JournalIssue CitedMedium="Internet"><Volume>398</Volume><Issue>6</Issue><PubDate><Year>2013</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Langenbeck's archives of surgery / Deutsche Gesellschaft für Chirurgie</Title><ISOAbbreviation>Langenbecks Arch Surg</ISOAbbreviation></Journal><ArticleTitle>Routine preoperative (111)In-octreotide scintigraphy in patients with medullary thyroid cancer.</ArticleTitle><Pagination><MedlinePgn>875-80</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00423-013-1086-1</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Surgery is the only potential cure for patients with medullary thyroid carcinoma (MTC). Preoperative ultrasound, computed tomography and magnetic resonance imaging are not sensitive enough for detection of microscopic disease. The aim of this study was to investigate if routine preoperative (111)In-labelled (DTPA-D-Phe(1))-octreotide scintigraphy (SRS) could be used as a staging procedure in planning primary surgery in patients with MTC.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">This study included patients with primary sporadic clinically overt MTC diagnosed between 1996 and 2009. All patients underwent conventional imaging of neck and thorax and SRS prior to standardised surgery. The findings on SRS were correlated to the findings on conventional imaging, histopathology and to postoperative biochemical results and survival.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">A total of 19 patients with sporadic MTC were enrolled. Median follow-up was 77(9-184) months. SRS visualised the primary tumour in 16 (84 %) patients. Fifteen (79 %) patients had locoregional lymph node metastases, but SRS detected metastatic lesions in only 8 (53 %) patients. In three patients with distant spread, SRS failed to detect metastatic lesions in two. At latest follow-up, six (32 %) patients had died, nine (47 %) patients were alive with elevated tumour markers, and four (21 %) patients were considered in complete biochemical remission.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This study provided further evidence that SRS, compared to conventional imaging, is fairly sensitive for detection of primary MTC but not metastatic disease. Although preoperative SRS may be of prognostic value, there is no indication for its routine use as a staging procedure in planning primary surgery.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dahlberg</LastName><ForeName>Jakob</ForeName><Initials>J</Initials><Affiliation>Department of Surgery, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden. jakob.dahlberg@vgregion.se</Affiliation></Author><Author ValidYN="Y"><LastName>Bümming</LastName><ForeName>Per</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Gjertsson</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Jansson</LastName><ForeName>Svante</ForeName><Initials>S</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>05</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Langenbecks Arch Surg</MedlineTA><NlmUniqueID>9808285</NlmUniqueID><ISSNLinking>1435-2443</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Radiopharmaceuticals</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>indium-111-octreotide</NameOfSubstance></Chemical><Chemical><RegistryNumber>RWM8CCW8GP</RegistryNumber><NameOfSubstance>Octreotide</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease">Thyroid cancer, medullary</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Diagnostic Tests, Routine</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Lymph Nodes</DescriptorName><QualifierName MajorTopicYN="N">pathology</QualifierName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Neoplasm Invasiveness</DescriptorName><QualifierName MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Neoplasm Staging</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Octreotide</DescriptorName><QualifierName MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Preoperative Care</DescriptorName><QualifierName MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Radiopharmaceuticals</DescriptorName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Risk Assessment</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Sensitivity and Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Survival Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Thyroid Neoplasms</DescriptorName><QualifierName MajorTopicYN="N">mortality</QualifierName><QualifierName MajorTopicYN="N">pathology</QualifierName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName><QualifierName MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Thyroidectomy</DescriptorName><QualifierName MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Tumor Burden</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>12</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>5</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2013</Year><Month>5</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>5</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>5</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>3</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1007/s00423-013-1086-1</ArticleId><ArticleId IdType="pubmed">23686276</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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